03-Jan-2014  1624 Download  Tushar G

Iontophoresis: An Electrically Assisted Drug Delivery System

 Tushar G, Rukari,Babita R. Alhat

At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks namely poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and inconvenient. New drug delivery system are also essential for the delivery of novel , genetically engineered pharmaceuticals (i.e. Peptides, Proteins) to their site of action, without incurring significant immunogenecity or biological inactivation.

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